Clemson, SC - October 1, 2016 - Memorial Stadium: Lamar Jackson (8) of the University of Louisville Cardinals during a regular season game (Photo by Allen Kee / ESPN Images)
Week 3 of our College Football Game of the Week picks takes us to Papa John’s Cardinals Stadium for a matchup of two ACC heavyweights as Clemson takes on Louisville.
The reigning national champions will try to top Heisman Trophy winner Lamar Jackson in a primetime bout.
Here’s Sports Spectrum’s picks for this week including a bonus upset pick.
Jason Romano: Clemson 42, Louisville 31 – Louisville is a tough out, especially at home, but Clemson’s defense should be good enough to limit Lamar Jackson. I like the Tigers on the road to get the win.
UPSET PICK: Mississippi State over LSU – The SEC opener for both teams should prove to be a physical contest. LSU appears to be the better team on paper here, but Mississippi State is home and I think they keep it close and pull off the upset.
Justin Adams: Clemson 31, Louisville 30 – Lamar Jackson accounted for six touchdowns last week. Mr. Heisman will be tough to stop but, I believe in Clemson’s defense which recorded 11 sacks last week against Auburn. Give me the Tigers and it’s strong defense to win in a thriller.
UPSET PICK: Vanderbilt over Kansas State – Kansas State is look for their first regular-season win against an SEC opponent since 1982. It’s won’t happen against an up-and-coming Vanderbilt team led by head coach Derek Mason, who’s itching for a marquee victory.
Jon Ackerman: Clemson 35, Louisville 24 – The defending national champs against the defending Heisman winner. A team is greater than one man, so I like Clemson and that D, which has yet to allow a touchdown this season, over Louisville QB Lamar Jackson, even if he’s playing at home.
UPSET PICK: San Diego State over Stanford – This might be the biggest game on SDSU’s schedule all year. After going 11-3 last year with a bowl win, and taking out Arizona State last week on the road, the Aztecs get Stanford at home. I can see them getting a statement win.
Jaxon Smith-Njigba in January 2026. (AP Photo/Godofredo A. Vásquez)
THIS IS THE SPORTS SPECTRUM PODCAST HOSTED BY ANNABELLE HASSELBECK, FEATURING JAXON SMITH-NJIGBA
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Today on the podcast, JSN joins Annabelle Hasselbeck to talk about his incredible 2025 season, signing a new four-year extension in March to make him the highest-paid NFL receiver in history, trusting in God’s plan, growing in his faith in Jesus, and believing the best is still yet to come.
BREAKING: Seahawks, WR Jaxon Smith-Njigba agree to terms on 4-year, $168.6M extension with $120M guaranteed, making him the highest paid WR in the NFL. (via @RapSheet) pic.twitter.com/krdA4gMRVe
Jacksonville Jaguars head coach Liam Coen, Nov. 2, 2025. (AP Photo/David Becker)
Despite going 13-4 and winning the AFC South a season ago under first-year head coach Liam Coen, the Jacksonville Jaguars have largely flown under the radar in offseason talks about potential Super Bowl contenders. Many experts predict the Jaguars to take a significant step back in 2026-27.
But as Coen enters his second year at the helm, with quarterback Trevor Lawrence returning, he believes his team can not only replicate last season’s success but continue to improve on it. If they do, it will mark the Jaguars’ first back-to-back postseason appearances this century.
“In everything that we do, we are training to say, ‘Anyone, any time, any way,'” Coen said as he addressed his team during the first week of training camp. “We built the standard and the foundation and the way that we want to play the game.”
At 40 years old, Coen is one of the younger head coaches in the NFL, and he’s also a member of the famed Sean McVay coaching tree; Coen learned under the Los Angeles Rams head coach as a position coach for three years (2018-20) and the offensive coordinator for another (2022). In 2024, Coen was the offensive coordinator for the Tampa Bay Buccaneers and helped fuel the career renaissance of QB Baker Mayfield. In his first year in Jacksonville last season, he became the NFL’s first rookie head coach to win 13 or more games after his team won four or fewer games the prior season.
During Coen’s coaching journey, he’s established himself as an offensive mastermind and a skilled quarterback developer. He’s also made it known during his time in the spotlight that he’s a follower of Christ.
Coen was a guest on the “Built 4 More” podcast last week with pastor Joby Martin and Denny Thompson, where the coach discussed one of the most difficult experiences of his life and how Christ formed his faith through the trial.
Coen grew up as an only child in Rhode Island, where he was a football fanatic and very close with his mother, Beth. But when Liam was in high school, Beth felt something was off. After numerous appointments, the doctors concluded that she’d contracted Lyme disease. The former marathon runner now struggled to get out of bed each morning. The physical pain was excruciating, and there was little improvement. But the emotional toll grew unbearable.
Four years later, in 2006, Coen was chasing his gridiron dream in college at UMass. He returned home during a school break, and his dad was in the hospital with congestive heart failure. While Coen was at the hospital with him, his mother took her own life.
Coen needed to care for his dad in the immediate aftermath, and then he rushed to return to school and join his team. Suddenly, he was back on a college campus, going to classes and practices like nothing had changed.
“I didn’t probably deal with it right, or well, in that short term,” Coen admitted on the podcast.
But this was different than anything he’d experienced before. The pain of losing his mother in the way he did wasn’t going away.
“Come to find out, 10 years down the road, it creeps up on you when you don’t deal with it,” he said on the podcast. “You don’t process it, you don’t forgive, you don’t have grace. It started to eat at me, and I didn’t know why. I didn’t know what was really happening. I wasn’t feeling right.”
He found people to talk through his traumatic past, and amidst those sessions, Jesus became a frequent topic of conversation. Coen had attended a private Catholic high school and learned many of the rituals, but he had never truly discovered the essence of Christianity.
“I actually began to have a relationship with Jesus Christ,” he said of that time. “And oh my gosh, I started to have more grace, and I started to forgive, and I started to have a little bit more understanding of what she went through and why.”
He had been given new life in Christ.
That new life was only strengthened during his time as the offensive coordinator and quarterbacks coach at Kentucky (2021, 2023) through the ministry of the school’s Fellowship of Christian Athletes (FCA) chapter. There, Coen was introduced to a man who handed him a small but extremely helpful packet about the Bible.
“I didn’t know what Jesus did,” Coen said on the podcast. “I didn’t know what He sacrificed. I didn’t know why He was truly put on this earth.”
Coen’s story of unthinkable pain followed by the power of healing found in Christ is a testimony of God’s goodness that he’s shared with his team and those close to him.
“Once I understood [true faith] and learned and was educated, I felt a different vibe,” he concluded. “I felt a different way of wanting to represent God — Jesus Christ, myself, my family, the way that I carry myself, the grace or honesty that you live life with.
“Perfect? Absolutely not. No question. But I know that it helped me when I actually built a relationship with a Power greater than myself in Jesus Christ.”
find someone who looks at you the way Liam Coen looks at Parker Washington
Now, in the hyper-competitive world of NFL football, with a nation’s eyes soon falling again on his sport, Coen has an opportunity to point others to Christ — the Fountain of true life — both in the 2026-27 season and beyond. Jacksonville’s first preseason game is Aug. 15 in New Orleans.
Mike Macdonald in February 2026. (AP Photo/Jeff Chiu)
THIS IS THE SPORTS SPECTRUM PODCAST HOSTED BY JASON ROMANO, FEATURING MIKE MACDONALD
Mike Macdonald was named the head coach of the Seattle Seahawks in 2024 and immediately made a big impact, leading the Seahawks to a Super Bowl championship in 2025-26. Prior to becoming the Seahawks head coach, he was a longtime assistant coach with the Baltimore Ravens, Georgia Bulldogs and Michigan Wolverines.
Today on the podcast, Mike Macdonald shares about winning the Super Bowl, developing a culture in Seattle, being outspoken about his faith, and what it means to “run it forward” in 2026.