The first week of games in December are headlined by a crucial NFC South matchup in the Big Easy. The New Orleans Saints (8-3) take on the Carolina Panthers (8-3) with the winner taking command of the division.

In Week 3, the Saints rolled over the Panthers 34-13 in Charlotte. Drew Brees tossed three touchdowns and the Saints defense picked off Cam Newton three times. Who will win in the rematch? Our experts make their picks below.

Jason Romano: New Orleans Saints 34 – Carolina Panthers 20 – New Orleans is really good at home and despite Carolina’s tough defense, I think Drew Brees and that Saints running game leads them to victory.

Justin Adams: New Orleans Saints 31 – Carolina Panthers 23 – New Orleans had a sloppy performance in Los Angeles last week, committing seven penalties for 112 yards. The Saints clean up the mistakes and get back to their winning ways by relying on the rushing attack of Mark Ingram and Alvin Kamara.

Jon Ackerman: New Orleans Saints 31 – Carolina Panthers 21 – It’s the No. 2 offense (Saints) against the No. 2 defense (Panthers) in terms of yards. I’ll take the offense at home.

Last Week’s Game of the Week Pick Recap:

Minnesota Vikings vs Detroit Lions

New Orleans Saints vs Los Angeles Rams

Jason Romano: Minnesota 25 – Detroit 17, New Orleans 27 – LA Rams 21

Justin Adams: Detroit 23 – Minnesota 20, New Orleans 30 – LA Rams 28

Jon Ackerman: Minnesota 27 – Detroit 14, Los Angeles Rams 33 – New Orleans 28

Actual Result: Minnesota Vikings 30 – Detroit Lions 23

Los Angeles Rams 26 – New Orleans Saints 20

Season Record: (Upsets Record in Parentheses) 

Jason: 9-4 (2-8)

Justin: 6-7 (4-6)

Jon: 9-3 (2-7)